2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0420S4
    Succinic acid-13C2-2 61128-08-3 98%
    Succinic acid-13C2 is the 13C labeled Succinic acid[1]. Succinic acid is a potent and orally active anxiolytic agent. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries[2][3].
    Succinic acid-13C2-2
  • HY-N0480AR
    Reserpine hydrochloride (Standard) 16994-56-2 98%
    Reserpine (hydrochloride) (Standard) is the analytical standard of Reserpine (hydrochloride). This product is intended for research and analytical applications. Reserpine hydrochloride is an inhibitor of the vesicular monoamine transporter 2 (VMAT2).
    Reserpine hydrochloride (Standard)
  • HY-N1369S1
    Menthol-d2 1335435-38-5 98%
    Menthol-d2 is deuterated labeled Menthol (HY-N1369). Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca++ currents in neuronal cell membranes.
    Menthol-d2
  • HY-N15339A
    Convolamine hydrochloride 5896-59-3 98%
    Convolamine hydrochloride is a tropane alkaloid and a potent Sigma-1 receptor positive allosteric modulator with an IC50 value of 289 nM. Convolamine hydrochloride can be extracted from Convolvulus plauricalis. Convolamine hydrochloride exhibits cognitive-improving and neuroprotective properties. Convolamine hydrochloride can be used in research related to Wolfram syndrome and Alzheimer's disease.
    Convolamine hydrochloride
  • HY-N2041S8
    Myristic acid-13C2 287111-20-0
    Myristic acid-13C2 is the 13C-labeled Myristic acid (HY-N2041). Myristic acid is an orally active saturated 14-carbon fatty acid found in most animal and plant fats, especially milk fat coconut oil, palm oil and nutmeg oil. Myristic acid exerts anti-inflammatory activity through the NF-κB pathway. Myristic acid has antibacterial, anti-inflammatory and analgesic properties.
    Myristic acid-13C2
  • HY-N2368AR
    Arecaidine hydrochloride (Standard) 6018-28-6 98%
    Arecaidine hydrochloride, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine hydrochloride is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake.
    Arecaidine hydrochloride (Standard)
  • HY-P10358A
    TAT-CBD3A6K acetate 99.76%
    TAT-CBD3A6K acetate, is a modified TAT-CBD3 peptide. TAT-CBD3A6K acetate reduces T- and R-type voltage-dependent calcium currents in dorsal root ganglion (DRG) neurons. TAT-CBD3A6K acetate shows anti-nociceptive effects in a model of AIDS-induced peripheral neuropathy by preventing CRMP-2-mediated enhancement of T- and R-type calcium channel function.
    TAT-CBD3A6K acetate
  • HY-P990137
    Anti-Rat CD28 Antibody (JJ319) 98%
    Anti-Rat CD28 Antibody (JJ319) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to rat CD28. Anti-Rat CD28 Antibody (JJ319) activates T cells in the presence of T cell receptor-stimulation. Anti-Rat CD28 Antibody (JJ319) can be used for the researches of inflammation and immunology, such as transplantation and neuritis.
    Anti-Rat CD28 Antibody (JJ319)
  • HY-P990793
    Anti-Mouse CD28 Antibody (D665) 98%
    Anti-Mouse CD28 Antibody (D665) is a mouse-derived agonistic IgG1 κ type antibody, targeting to mouse CD28. Anti-Mouse CD28 Antibody (D665) induces the activation of T cells. Anti-Mouse CD28 Antibody (D665) can be used for the researches of neurological disease, inflammation, immunology and cancer, such as Parkinson disease (PD), arthritis and graft-versus-host disease (GVHD).
    Anti-Mouse CD28 Antibody (D665)
  • HY-P990819
    Anti-Rat CD28 Antibody (JJ316) 98%
    Anti-Rat CD28 Antibody (JJ316) is a mouse-derived agonistic IgG1 κ type antibody, targeting to rat CD28. Anti-Rat CD28 Antibody (JJ316) can induce T cell proliferation. Anti-Rat CD28 Antibody (JJ316) can be used for the researches of inflammation, immunology and neurological disease, such as experimental autoimmune encephalomyelitis (EAE) and graft-versus-host disease (GvHD).
    Anti-Rat CD28 Antibody (JJ316)
  • HY-P99123A
    Anti-Mouse CD28 (LALA-PG) Antibody (D665) 98%
    Anti-Mouse CD28 (LALA-PG) Antibody (D665) is an anti-mouse CD28 IgG2a monoclonal antibody. Anti-Mouse CD28 (LALA-PG) Antibody (D665) is a chimeric antibody of the original D665 antibody (HY-P990793). Anti-Mouse CD28 (LALA-PG) Antibody (D665) contains the LALA-PG mutation region. Anti-Mouse CD28 Antibody (D665) induces the activation of T cells. Anti-Mouse CD28 Antibody (D665) can be used for research on neurological conditions, inflammation, immunology and cancer, such as Parkinson disease (PD), arthritis and graft-versus-host disease (GVHD).
    Anti-Mouse CD28 (LALA-PG) Antibody (D665)
  • HY-P992512
    ANX-M1 (Mouse IgG1) 98%
    ANX-M1 Mouse IgG1 is a brain-penetrant C1q inhibitor. ANX-M1 Mouse IgG1 blocks classical complement pathway activation, reduces C1q concentrations in brain and plasma, and inhibits microglia-mediated synapse engulfment. ANX-M1 Mouse IgG1 can be used for the research of Huntington's disease, Alzheimer's disease, retinopathy and neuropathic pain.
    ANX-M1 (Mouse IgG1)
  • HY-RS16306
    Lgi4 Mouse Pre-designed siRNA Set A 98%

    Lgi4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lgi4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Lgi4 Mouse Pre-designed siRNA Set A
  • HY-RS29451
    Actg1 Rat Pre-designed siRNA Set A 98%
    Actg1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Actg1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Actg1 Rat Pre-designed siRNA Set A
  • HY-U00001A
    Phenglutarimid hydrochloride 1674-96-0 98%
    Phenglutarimid hydrochloride is an anticholinergic used as an antiparkinsonian agent.
    Phenglutarimid hydrochloride
  • HY-U00134R
    Benzcyclane (Standard) 2179-37-5 98%
    Benzcyclane (Standard) is the analytical standard of Benzcyclane (HY-U00134). This product is intended for research and analytical applications. Benzcyclane (Bencyclane; Benzcyclan) is a serotonin receptor antagonist and a cerebral/peripheral vasodilator. Benzcyclane exerts atypical serotonin antagonistic effects in rabbit superior mesenteric arteries. Benzcyclane relaxes high K+-induced contractions in rabbit basilar arteries and superior mesenteric arteries, and selectively inhibits sympathetic nerve stimulation-induced contractions in rabbit pulmonary arteries. Benzcyclane exerts non-competitive norepinephrine antagonistic effects in rabbit superior mesenteric arteries, and slightly reduces the maximum contractile response induced by histamine. Benzcyclane relaxes smooth muscles, induces transient hypotension, inhibits thrombosis, and accelerates blood fibrinolytic activity. Benzcyclane increases cerebral glucose content/uptake, enhances hypoxia tolerance in mice, and increases cerebral blood supply in dogs. Benzcyclane is applicable to studies related to cerebral vascular circulation.
    Benzcyclane (Standard)
  • HY-U00153R
    Dixyrazine (Standard) 2470-73-7
    Dixyrazine (Standard) is the analytical standard of Dixyrazine. This product is intended for research and analytical applications. Dixyrazine, a phenothiazine derivative, can prevent brain oedema induced by intracarotid injection of protamine sulphate.
    Dixyrazine (Standard)
  • HY-U00228R
    Rilmazafone hydrochloride (Standard) 85815-37-8 98%
    Rilmazafone hydrochloride (450191S) is a benzodiazepine (omega) ligand.
    Rilmazafone hydrochloride (Standard)
  • HY-U00230A
    CDD0102 hydrochloride 1196130-86-5 98%
    CDD0102 Hydrochloride is a potent M1 Muscarinic receptor agonist.
    CDD0102 hydrochloride
  • HY-W007223
    D-5-Hydroxytryptophan 4350-07-6 98%
    D-5-Hydroxytryptophan (D-5-HTP) is the D-isomer of 5-HTP and can be isolated from DL-5-hydroxytryptophan by continuous separation. Compared with intraperitoneal administration of L-5-Hydroxytryptophan, which can induce dose-dependent backward walking behavior in mice, D-5-Hydroxytryptophan has no significant effect on mouse behavior and is a negative control. D-5-Hydroxytryptophan is also a 5-HT ligand, capable of binding to the 5-HT site with affinity in the micromolar range.
    D-5-Hydroxytryptophan
Cat. No. Product Name / Synonyms Application Reactivity